Rolac

Kerorolac tromethamine

Description

Rolac contains ketorolac tromethamine which is a member of the pyrrolopyrrole group of no steroidal anti-inflammatory drugs that exhibits analgesic anti inflammatory and antipyretic activity it has more pronounced amalgesic activity than ost nsaids ketorolac inhibits synthesis of prostaglandins any may be considered a peripherally acting analgesic ketorolac tromethamine 3 mg intramuscularly appears to be similar in efficacy to morphine 12 mg intramuscularly appears to be similar in efficacy to motphine 12 mg and superior to pethidine 100 mg it has no opioid activity and thus does not present a problem of addiction

Composition

Rolac tablet each film coated tablet contains ketorolac tromethamine usp 10 mg

Indication

Rolac ampoules are indicated for the short term management of moderate to severe acute postoperative pain

Rolac tablet are indicated for the short term management of moderate postoperative pain

Dosage and administration

Rolac ampoules ara for administration by intramuscular or bolus intravenous injection bolus intravenous doses should be given over no less than 15 seconds rolac ampoules should not be used for epidural or spinal administration the time to onset of analgesic effect following both i.v and i.m administration is similar and is approximately 30 minutes with maximum analgesia occurring within 1 to 2 hours the median duration of analgesia is generally 4 to 6 hours dosage should be adjusted according to the severity of the pain and the patient response duration of treatment the administration of continuous multiple daily doses of rolac intramuscularly or intravenously should not exceed 2 days because adverse event may increase with prolonged usage threw has been limited experience with dosing for longer periods since the vast majority of patients have transferred to oral medication or no longer require analgesic therapy after this time rolac tablets are recommended for short term use only up to 7 days and are not recommended for chronic use adults ampoules the recommended initial dose of rolac is 10 mg followed by 10-30 mg every 4to 60 hours as requited in the initial postoperative period rolac may be given as often

Contraindication

A history of poetic ulcer of gastrointestinal bleeding suspected or confirmed cerebrovascular bleeding hemorrhagic diatheses including coagulation disorders patients with hypersensitivity to kerolac tromethazine or other naiads and patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions

Side effects

Gastro intestinal nausea dyspepsia gastro intestinal pain abdominal discomfort bowel changes gastritis diarrhea   

Precautions

Physicians should carefully weigh the potential risks and benefits of its use on a long term basis patients should be instructed to watch for signs of serious GL adverse events and they should monitored more closely than if they were on another NSAID.