Flexi

Aceclofenac BP

Composition

Flexi tablet ach film coated tablet contains aceclofenac BP 100mg

Pharmacology

Flexi aceclofenac is a non steroidal agent with market anti inflammatory and analgesic oroperties it is a pitent inhibitor of the enzyme cyclooxigenase which is involved in the oroduction of prostaglandin after oral administration  aceclofenac is rapidly and completely absorbed as unchanged drug peak plasma concentrations are reached approxi mately 1.25 to 3.00 hours following ungestion aceclofenac penetrates into the synovial fluid where the concentrations reach approximately 57% of those in plasma the mean oplasma elimination half life is around 4 hours aceclofenac is highly portion bound aceclofenac circulates mainly as unchanged drug 4 hydroxy aceclofenac is the main metabolite detected in plasma approximately two thirds of the administered dose is excreted via the urine mainly as hydroxyme tabolites

Indication

For the relief of pain and inflammation in osteoarthists rheumatoid arthritis and ankylosing spondylitis  

Dosage and administration

Adult the recommended dose is 100mg twice daily

children there are no clinical data on the use of aceclofenac in children

elderly the pharmacokinetics of aceclofenac is not altered in elderly patients therefore it is not considered necessary to modify the dose or dose frequency

Contraindication and precaution

Aceclofenac should not be administered to patients with active or suspected peptic ulcer or gastric intestinal bleeding it should not be given to patients with moderate to severe renal impairment close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function ir should not be prescribed during pregnancy unless there are compelling reasons for doing so the lowest effective dosage should be used aceclofenac should not be administered to patients previously sensitive to aceclofenac or in whom aspirin or NSAIDs precipitate arracks of asthma acute rhinitis or urticaria or who are hypertensive to these drugs

Side effects

The majority of side effects observed have been reversible and of a minor mature and include gastro intestinal disorders dyspepsia abdominal pain nausea and diarrhea and occasional occurrence of dizziness dermatological complaints including pruritus and rash and abnormal hepatic enxyme levels and raised serum creatinine have occasionally been reported.

Drug interaction

Lithuma and digoxim aceclofenac like many NSAIDs may increase plasma concentrations of  lithium and digoxin.