Don A

Domperidone

Description

Don A is a dopamine antagonist that principally blocks the dopamine receptors located in the chemoreceptor trigger zone and stomach its gastro prokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of gastro intestinal tract due to its weak penetration across the blood brain barrier Don A has almost no effect on the dopaminergic receptors in the brain therefore excluding psychotropic and neurologic side effects Don A restores normal motility and tone of the upper gastro intestinal tract facilitates gastric emptying enhances antral and duodenal peristalsis and regulates contraction of the pylorus Don A also increases esophageal peristalisis and lower esophageal sphincter pressure and thus prevents regurgitation of gastric content

Indications

Don A is indicated for

Stimulation of gut mobility

a)     Non ulcer dyspepsia

b)    Esophageal reflux, reflux esophagitis and gastritis

c)     Diabetic gastro paresis

d)    Functional dyspepsia

e)     Speeding barium transit in follow through radiological studies.

Dosage and administration

Dose and frequency of administration should be adjusted according to severity and duration of symptoms Don A tablet suspension and paediatric drops should be taken minutes before meal.

Contraindications

Domperidone is contraindicated to the patients with known hypersensitivity to this drug and in case of neonates

Precautions

Domperidone should be used with absolute caution in case of children because there may be increased risk of extra pyramidal reactions in young children because of an incompletely developed blood brain barrier since Domperidone is highly metabolized in liver it should be used with caution in patients with hepatic impairment

Side effect

The common side effect of Domperidone is hyperprolactinemia which may result in galactorrhea breast enlargement soreness and reduced libido other side effects are dry mouth thirst headache nervoudness drowsiness diarrhea skin rash and itching which may occur during treatment with Domperidone extra pyramidal reactions are seen in 0.05% of patients in clinical studies.